Silymarin or milk thistle medicine : Indication, Dosage

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In this blog, we learn about silymarin medicine. It is very useful medicine to treat hepatitis, jaundice, liver disorder, etc.

silymarin medicine
milk thistle plant (silymarin)

Silymarin or milk thistle is a flower herb related to the daisy and ragweed family. It is native to Mediterranean countries.

Traditionally, this herb is use for liver & gall bladder problems. Silymarin is an antioxidant compound taken from milk thistle seeds. It is helpful in liver disorders, hepatitis, cirrhosis, jaundice, gall bladder disorder, etc.

We learn this topic in below format

INDICATION

This medicine is helpful in below conditions

  • Hepatitis A
  • Chronic active hepatitis
  • Toxic metabolic hepatic damage
  • Amanita phalloides poisoning
  • carbon tetrachloride poisoning
  • adjuvant treatment in cirrhosis & alcoholic hepatitis
  • Gall bladder related disorder

CONTRAINDICATION

This is more important than indication. Because we must know the conditions when not to give this medicine.

  • hepatic encephalopathy
  • obstructive jaundice
  • primary biliary cirrhosis
  • hypersensitivity to silymarin

DOSAGE

Hepatic disorder
140 mg twice or thrice in a day

Children
10mg/kg body weight
Below dosage is given as per age, kindly corelate dose with weight if needed

Age
0-2 years – 105mg per day
3-7 years – 210mg per day
8-12 years – 315mg per day
13 or above Р420mg per day 

SIDE-EFFECT

There is no major side-effect reported of silymarin. If adverse effect occurs, it may be related to your complain of liver diseases like

  • Nausea.
  • Diarrhea.
  • Intestinal gas.
  • Fullness or pain in the stomach.
  • Loss of appetite.
  • Rashes and itching.

MECHANISM OF ACTION

Silymarin reduces the turnover of membrane phospholipids and stabilises cell membranes of hepatocyte. It also has potent antioxidant action and prevents lipid peroxidation

BRAND NAMES & STRENTH

It is available in market with different brand names like Silybon, Silymar, Higado, Limarin, Siliv, etc.

Strenth
35mg/5ml
70mg tablet
140mg tablet

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