In This blog, we learn about Paracetamol medicine which is available under the brand name of Penadol, Calpol, etc. Other name of paracetamol is acetaminophen. This medicine is commonly used to treat fever and mild to moderate pain.
We learn this medicine in below format
- Basic information
- Mode of action
- Side effect
- Special precaution
- Pregnancy & lactation
Earlier medicine used for fever and pain are acetanilide and phenacetin but it has more side-effect. These drug causes cyanosis due to methemoglobinemia.
Paracetamol was first marketed in the United States in 1950 under the name of Triagesic.
This medicine is on the counter (OTC) product. It means we do not required doctor’s prescription to buy this medicine.
It is one of the essential medicine in list of World Health Organization (WHO).
MODE OF ACTION
How paracetamol controls fever?
|Normal body temperature is 98.6 F, which is regulated by hypothalamus (brain)|
|When infection occurs, there is increase secretion of prostaglandin|
|Which causes disturbance in hypothalamus & due to that temperature increases called fever|
|After taking paracetamol, this medicine blocks the synthesis of prostaglandin|
So, for period of time hypothalamus works well & temperature decreases.
This way paracetamol decreases the temperature for short period of time. Other medicines will control the infection.
How paracetamol controls the pain?
|When we got injury, there is increase secretion of prostaglandin by our body|
|It causes nerve stimulation & so, we feel pain|
|After taking paracetamol, it blocks the synthesis of prostaglandin|
This way paracetamol controls pain. With time injured part heal & patient will feel completely okay.
|10-15 mg/kg per dose|
|10kg||150mg||three time or every 4 hours|
|20kg||300mg||three time or every 4 hours|
|Adult||500mg or 650mg||three time or every 4 hours|
|Maximum dosage – 4000mg (4gm) per day|
Each & every molecule which have effect also have side-effect. But, it not occurs to everyone. It occurs to only who have sensitivity to particular molecule.
If adverse effect occurs, that may be one of below
- Liver damage in overdose
- Liver disease
- Kidney disease
STRENGTH & BRAND NAMES
This medicine is available in tablet, capsule, injection form.
Brand names : Calpol, dolo, T98, 99F, panadol
Available strenth are as below
PARACETAMOL IN PREGNANCY & LACTATION
This medicine is safe in both pregnancy & lactation.
But we should avoid prolonged use of paracetamol in pregnancy and use it only when necessary, at the lowest effective dosage and for the shortest time.
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