Nimesulide medicine : Indication, Dosage, Side effect


In this blog, we learn about Nimesulide medicine which is available under the brand name of nimeson, nise, etc. 

nimesulide medicine
structure of nimesulide

This medicine is commonly used to treat fever and mild to moderate pain & inflammation in adolescent and adults above 12 years of age.

Nimesulide is not available in the United States, however it used in other countries for acute pain. Nimesulide is not advise to take for long-term, as for chronic conditions such as arthritis. Because taking it for long term may harm liver including liver failure.

In 1985, it was marketed as brand name of aulin & mesulid in Italy & it is available in more than 50 countries worldwide.

Nimesulide has never been filed for Food and Drug Administration (FDA) evaluation in the United States, where it is not marketed.

We learn this medicine in below format


  1. Fever
    It reduces the high body temperature
  2. Inflammation
  3. Pain
    It is useful to treat mild to moderate pain, conditions mention as below

    nimeson in body pain
    body pain
    • Rheumatoid arthritis
    • Osteoarthritis
    • Low backache
    • Menstruation related pain & other gynecological conditions
    • Dental pain
    • Pain after operation
    • ENT Inflammation
    • Trauma or injury 
    • Thrombophlebitis – inflammation of the wall of vein associated with thrombosis


  • If person having hypersensitivity to this molecule
  • In liver disease


100mg twice daily.

Effect of nimesulide starts within 30-60 minutes & effect last for 8 to 10 hours.


Due to concerns about the risk of liver toxicity, nimesulide has been withdrawn from market in several countries (Spain, Finland, Belgium, Ireland, and United States). Liver problems  results in both deaths and the need for transplantation. This may occur in short period as three days after starting the medication.

Continuous use of nimesulide (more than 15 days) may cause the following side effects:

  • Nausea, vomiting, diarrhoea
  • Epigastric distress
  • Headache
  • Rashes
  • Acidity, heart burn
  • Dizziness, sleepiness


  • Use cautiously in liver & kidney problem
  • Congestive heart failure
  • Volume or salt depression
  • Not to give below age of 12 years of age.


How it controls fever

Normal body temperature is 98.6 F, which is regulated by hypothalamus (brain)

When infection occurs, there is increase secretion of prostaglandin 

Which causes disturbance in hypothalamus & due to that temperature increases called fever

After taking nimesulide, this medicine blocks the synthesis of prostaglandin 

So, for period of time hypothalamus works well & temperature decreases.

This way it decreases the temperature for short period of time. Other medicines will control the infection. 

How it controls the pain?

When we got injury, there is increase secretion of prostaglandin by our body

It causes nerve stimulation & so, we feel pain

After taking nimesulide, it blocks the synthesis of prostaglandin 

So, brain not recieved the message of pain temporarily

This way nimesulide controls pain. With time injured part heal & patient will feel completely okay.

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