Ibuprofen : Indication, Side-effect, Dosage

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In this blog, we learn about Ibuprofen medicine which is available under the brand name of brufen. This medicine is commonly used to treat fever and mild to moderate pain & inflammation.

We learn this medicine in below format

BASIC INFORMATION

Ibuprofen medicine is in NSAID class. It means it is non steroidal anti-inflammatory drug. It is commonly used to treat fever, mild to moderate pain & Inflammation.

Discovered in 1961 by Stewart Adams & initially marketed as Brufen.

It is one of the essential medicine in list of World Health Organization (WHO).

INDICATION

To control fever
It helps to reduce high temperature 

To control any kind of mild to moderate pain

  • Osteoarthritis
  • Rhumatoid arthritis
  • Musculoskeletal disease
  • Soft tissue injury
  • Dysmenorrhea – pain during menses
  • Dental pain
  • Cervical pain
  • Post surgical pain

CONTRAINDICATION

It means we should not give this medicine to the patient, who have below complains. •

  • Peptic ulcer
  • GI bleeding
  • Asthma
  • Heartburn
  • Sensitivity to this particular molecule

Your doctor may add acid regulator medicine along with ibuprofen. So, patient will not suffer from any gastric discomfort.

SIDE EFFECT

Each & every molecule which have effect also have side-effect. But, it not occurs to everyone. It occurs to only who have sensitivity to particular molecule.

If adverse effect occurs, that may be one of below

  • Nausea, vomiting
  • Headache
  • Rashes
  • Breathlessness/wheezing
  • Heartburn

DOSAGE

Not to give below 7kg weight
10-15 mg/kg per dose
Weight mg Time
10kg 150mg Three time in a day
20kg 300mg Three time in a day
Adult 400mg Three time in a day

 

MODE OF ACTION

How it controls fever?

Normal body temperature is 98.6 F, which is regulated by hypothalamus (brain)
When infection occurs, there is increase secretion of prostaglandin
Which causes disturbance in hypothalamus & due to that temperature increases called fever
After taking ibuprofen, this medicine blocks the synthesis of prostaglandin
So, for period of time hypothalamus works well & temperature decreases.

 

This way Ibuprofen decreases the temperature for short period of time. Other medicines will control the infection. 

How it controls the pain?

When we got injury, there is increase secretion of prostaglandin by our body
It causes nerve stimulation & so, we feel pain
After taking ibuprofen, it blocks the synthesis of prostaglandin 
So, brain not recieved the message of pain temporarily

 

This way ibuprofen controls pain. With time injured part heal & patient will feel completely okay.

STRENGTH & BRAND NAMES

This medicine is available in tablet & liquid form.

  • Brand names
    Brufen

    ibuprofen tab
    ibuprofen (brufen 400)
  • Strenth
    200mg & 400mg tablet

It is also available in combination with paracetamol like

  • Combiflam

    ibuprofen and paracetamol
    ibuprofen combination
  • Flexon
  • Ibugesic
  • Strenth
    100mg ibuprofen + 162mg paracetamol
    400mg ibuprofen + 325mg 

IBUPROFEN IN PREGNANCY 

A study of pregnant woman suggest that those taking any type or amount of NSAIDs (including ibuprofen, diclofenac, naproxen) were 2.4 times more likely to miscarry comparative to those who are not taking any medications.

However, Israeli study found no increase risk of miscarriage in the group of pregnant woman.

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