Granisetron medicine : Indication, Dosage, Side-effect

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In this blog, we learn about Granisetron medicine which is sold under brand name of Kaytril, graniforce, etc. 

granisetron medicine
granisetron structure

This is antiemetic medicine which use to treat nausea and vomiting in cancer, radiotherapy, chemotherapy, gastric disturbance, etc. It does not have much effect in vomiting due to motion sickness.

Granisetron was developed by chemists working at the British drug company Beecham around 1988 and it is available in market as a generic medicine. Roche Laboratories produces thi medicine under the brand name of  Kytril. The drug was approved in the U.K. in 1991 and in U.S.A. in 1994 by the FDA.

Granisetron is metabolized slowly by the liver, giving it a longer than average half-life. One dose usually lasts 4 to 9 hours and is usually administered once or twice in a day. This drug is removed from the body by the liver and kidneys.

We learn this topic in below format

INDICATION

granisetron effect on vomiting
nausea & vomiting
  • Nausea & vomiting associated with cancer, radiation & chemotherapy
  • Postoperative nausea and vomiting
  • Nausea & vomiting due to gastric disturbance or in dehydration
  • Cyclical vomiting syndrome in which vomiting lasts for hours to days in patient. It mostly occurs to those who have migraine or having family history of migraine.

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MECHANISM OF ACTION

It is very potent medicine & it is highly selective 5- HT3 antagonist. This way it block the 5- HT3 receptor & giving relief in nausea and vomiting.

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DOSAGE

Dosage may be vary from condition to condition.

Adult
1mg twice daily before meal or before chemotherapy or other treatment.

Children (2 to 16 years)
10 micrograms per kg
It means that if child have 15kg weight than we can give 150 micron (0.15mg).

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CONTRAINDICATIONS

  • Hypersensitivity to this molecule
  • Children below 2 years of age

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ADVERSE EFFECT

Each & every molecule which have effect, it has also side-effect. We can not deny adverse effect or side-effect. But it is not happen to everybody, it only occurs to someone who have sensitivity to particular molecule.

If patient have known sensitivity to any medicine, than they should show it to your consulting doctor.

If adverse effect occurs than it may be one of below

  • Anxiety
  • Dizziness
  • Fever
  • Weakness
  • Sleepiness or inable to sleep
  • Elevation of liver enzyme (AST & ALT)

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SPECIAL PRECAUTIONS

Use granisetron cautiously in

  • Liver disease
  • Constipation
  • Headache.

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BRAND NAMES & STRENTH

This medicine is available in both oral tablet form & in injection form.

Brand names
kaytril, graniforce, sancuso, etc.

Strenth
1mg per ml in injection form
1mg in tablet form
Pediatric use – 1mg in 5 ml syrup

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