Doxycycline meidicne : Indication, Dosage, Side-effect

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In this blog, I will give you information regarding Doxycycline medicine which is available in market under brand names like doxy1, monodox, adoxa, etc. 

doxy structure
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Doxycycline is a broad spectrum tetracycline class of medicine which use to treat many bacterial infection. It has also antiviral property as per studies, so its use in covid19. 

Doxycycline was patented in 1957 and came into commercial use in 1967. It is on the essential medicine as per World Health Organization. It is available as a generic medicine.

We learn this topic in below format

INDICATION OF DOXYCYCLINE

It is very useful to treat below conditions. I ordered the disease names from head to toe. So, it will be easier to understand & remember.

  • Eye infection
  • Ear-Nose- Throat (ENT) Iinfection
  • Dental infection
  • Acne
  • Sinusitis
  • Respiratory tract infection
  • Genito-urinary tract infection
  • Venereal disease
  • Chronic prostitis
  • Gynaecological infection
  • Pelvic inflammatory disease
  • Brucellosis
  • Cholera
  • Ricketsial infection
  • Covid19 & doxycycline 
    Studies suggest that doxycycline have antiviral effect also. So, it is useful medicine in covid19 viral infection.

CONTRAINDICATION

Avoid doxycycline medicine in below conditions

  • Patient having sensitivity to this molecule or tetracycline group
  • Porphyria (blood disorder)
  • Systemic lupus erythematous

DOSAGE OF DOXYCYCLINE

Adult
100mg once or twice in a day as per disease condition.

Children
5mg/kg/day in two divided doses

Effect of medicine starts within 4-6 hours after taking it & effect last in body for approx 24hours.

SIDE-EFFECT 

Each & every molecule which have effect also have side-effect. But, it not occurs to everyone. It occurs to only who have sensitivity to particular molecule.

If adverse effect occurs, that may be one of below

  • Nausea, vomiting, diarrhoea
  • Rash or itching
  • Light sensitive rash

SPECIAL PRECAUTION

Pregnancy
Doxycycline or other tetracycline may cause Discoloration the teeth of the developing fetus. So, this medicine should be avoid in pregnancy.

Use cautiously in liver disease

Not recommended under 12 years of age

MECHANISM OF ACTION

Doxycycline, like other tetracycline antibiotics, is bacteriostatic. It means it work by preventing bacteria from reproducing through the inhibition of protein synthesis.

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