Domperidone medicine : Indication, Dosage, Side-effect

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In this blog, we learn about Domperidone medicine which is sold under brand names like domstal, vomistop, motilium, etc. Domperidone medicine is antiemetic, it means it use to relieve nausea & vomiting due to many conditions. It is available in tablet & suspension form.

domperidone medicine
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In 1974, Domperidone synthesized at Janssen Pharmaceutical following the research on antipsychotic drugs.

We learn this topic in below format

INDICATION OF DOMPERIDONE

This medicine is useful to treat & relieve nausea & vomiting due to any cause, mention below

domperidone in nausea & vomiy
nausea & vomit
  • Nausea or vomiting due to any medicine
  • After operation
  • Due to radiation
  • Uraemia
  • hepatitis
  • peptic ulcer
  • reflux oesophagitis
  • diabetic gastroparesis
  • functional dyspepsia
  • adjuvant in vertigo with nausea

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CONTRAINDICATION

It is more important than indication. We must know the conditions in which we should avoid this medicine.

  • Gastro intestinal obstruction
  • Gastro intestinal perforation
  • Hypersensitivity to this molecule
  • Extrapyramidal symptoms
  • Phaeochromocytoma
  • Epilepsy

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DOSAGE OF DOMPERIDONE

Dosage may depend on severity of complain, age & weight. Kindly follow your doctor advise for dosage.

Adult
10-20mg three to four time in a day before meal

Childen
0.3mg/kg body weight per dose
10kg child – 3mg three time in a day
20 kg child – 6mg three time in a day

Onset of effect of domperidone starts within 1 hour after taking it & effect last for approx 6 hours after taking it.

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SIDE-EFFECT

Each & every molecule which have effect also have side-effect. But, it not occurs to everyone. It occurs to only who have sensitivity to particular molecule.

If adverse effect occurs, that may be one of below

  • Drowsiness & extra pyramidal reaction
  • Convulsion
  • Galactorrhea (raised serum prolactin)
  • Muscle spasm
  • Rashes over body
  • Breast enlargement
  • Constipation or diarrhoea
  • Hypertensive crisis in patient with pheochromocytoma

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SPECIAL PRECAUTION

  • Use cautiously in kidney disease
  • Cautiously use in predisposition to cardicac arrythmias or hypocalaemia

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MECHANISM OF ACTION

Domperidone antagonises D2 receptor & it antagonizes the inhibitory effect of dopamine. It results into stimulation of gastric muscle contraction. Due to that we get relief in nausea & vomiting.

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BRAND NAMES & STRENTH

It is available in market under brand names like Domstal, Vomistop, Motilium, etc.

Strenth
5mg tablet
10mg tablet
20mg tablet
30mg capsule
10mg per ml oral drop

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