In this blog, we learn about chloroquine medicine. Which is sold under brand names like aralen, lariago, etc.
This medicine is primarily use for to prevent and treat malaria fever caused by mosquito bite.
Certain type of malaria, resistant strains or complicated cases typically require other or additional medicines.
We learn this topic in below format
- Mechanism of action
- Onset of effect
- Adverse effect
- Special precaution
INDICATION OF CHLOROQUINE
- To prevent & treat malaria fever like plasmodium vivex, p.ovale, p.malariae. It is not indicated in p.falciparum because there is widespread resistance to it.For prevention, take chloroquine as directed by your doctor, usually once a week on the same day each week. Note dates in calendar to help you remember. This drug is usually started 1 to 2 weeks before entering the malaria infected area. Continue to take it weekly while in the area and for 4 to 8 weeks after leaving the area, or as directed by your consulting doctor.
- Amoeba hepatitis
- Discoid lupus erythematous
- Photo allergic reaction
- Rheumatoid arthritis
MECHANISM OF ACTION
Chloroquine inhibit the formation of hemozoin (Hz) from the heme released by the digestion of haemoglobin. The free heme then rupture and leads to parasite death.
DOSAGE OF CHLOROQUINE
Dosage can be change as per disease severity or other factor. So, kindly consult doctor & follow advise before taking medicine.
1000mg stat (base molecule is 600mg)
500mg after 6 hours (base molecule is 300mg)
500mg once (base 300mg) after 24hours of taking first dose
500mg once (base 300mg) after 48hours of taking first dose
250mg tablet once weekly, start 1-2 week before entering endemic area, take throughly once weekly till you stay there & 4 to 6 week after leaving that area.
5mg/kg after 6 hours
If person have G6PD deficiency, than we should avoid this medicine to that person. It may cause hemolysis after giving this medicine to G6PD deficient. If patient not having G6PD report than better to check it before giving this medicine.
If person have hypersensitivity to this molecule than also we should avoid this medicine to that patient.
ONSET OF EFFECT
SIDE-EFFECT OF CHLOROQUINE
Each & every molecule which have effect, it has also side-effect. We can not deny adverse effect or side-effect. But it is not happen to everybody, it only occurs to someone who have sensitivity to particular molecule.
If patient have known sensitivity to any medicine, than they should show it to your consulting doctor.
If adverse effect occurs than it may be one of below
- Use cautiously in chronic kidney or liver problem
- Patient having eye or vision problem
BRAND NAMES & STRENTH
It is available in market with brand names like Lariago, Leoquin, melubrin, etc.
It is available in below strength
Hope you like the article. To read other medical topics in easy language than Click Here