Cefixime : Indications, Dosage, Side-effect

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In this blog,I will give you information regarding Cefixime antibiotic.

Antibiotic means medicine which inhibit growth or destroy bacteria. There are many antibiotics available today in market. It is differenciate under groups.

Cephalosporin group contain medicines like cefixime, cefpodoxime, ceftriaxone, cefuroxime, cefadroxil, cephalaxin, etc.

cefixime cephalosporin antibiotic
Cefixime

Cefixime is third-generation cephalosporin antibiotic. It is oral medicine, it is not available in injection form. Cefixime was patent in 1979 and since 1989 it is approved for medical use in USA. As per WHO cefixime is most essential, effective and safest medicine.

We learn this content in below format,

INDICATION OF CEFIXIME

  1. Respiratory tract infection (RTI)
    Throat infection,Pneumonia,bronchitis, etc
  2. Urinary tract infection (UTI)
  3. Ear problem – otitis media
  4. Gonorrhoea – sexual transmitted disease
    In this disease discharge comes from penis & also causes urinary problem.
  5. Billiary tract infection
  6. Typhoid feverUsefull to kill gram +ve, gram -ve and also anaerobic bacteria.

MECHANISM OF ACTION

The bactericidal action of Cefixime antibiotic is due to the inhibition of cell wall synthesis. It binds to one of the penicillin binding proteins called PBPs, which inhibits the final transpeptidation step of the peptidoglycan synthesis in the bacterial wall. This way inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.

Absorption
Only 40-50% is absorbed from the GI tract, it is called oral bioavailability. Absorption may be decrease when taken with food. Oral suspension has higher average peak concentration approx 25-50% than oral tablet or capsule.

Distribution
Cefixime has high concentration in bile and urine. It can cross placenta and its protein binding capacity is approx 65%.

It is always better to do cultures and susceptibility studies to determine the causative organism and its sensitivity to cefixime.

DOSAGE

This is most important part. Because once you choose medicine you have to also select proper dosage as per weight of patient.

Dosage is : approx 10mg/ KG/ day in two divided doses.

For eg.

10 KG child – 100mg/day – 50mg + 50mg

20 KG child – 200mg/day – 100mg + 100mg

40kg or more – 400mg/day – 200mg + 200mg

This way dosage is calculate.If weight is more than 40KG than also dosage will be same as above mention.Onset of effect of this medicine is within 30 minutes.

ADVERSE EFFECT

Each and every medicine has side-effect but it occur to only them who have sensitivity to that particular molecule.

If patient have sensitive to any medicine than they must take sensitivity report with them while consulting doctor to avoid side-effect.

If side-effect occurs after taking medicine than it may occur as below mention

  • GI disturbance (gastro-intestinal disturbance)
  • Headache
  • Dizziness
  • Rashes

SPECIAL PRECAUTION

  • Children below 6 months
  • Renal impairment (kidney problem)
  • Those patient have sensitivity with penicillin

BRAND NAMES

  • ZIFI made by FDC
  • CEFTAS made by INTAS
  • MAHACEF made by MANKIND
  • CEFOLAC made by Macleods

Cefixime medicine is available in different strength as below

  • 25mg drop
  • 50mg liquid & tablet
  • 100mg liquid & tablet
  • 200mg tablet

Hope this article will be helpful to you.Kindly message me if you have any kind of query. Also you can watch video on same topic by click below link.

 

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