In this blog, we learn about Atorvastatin medicine which is sold under the brand names like lipitor, torvalds, caduet, torvasan, etc.
It is statin medicine which control abnormal lipid level & helpful in risk of cardiovascular disease. For prevention of cardiovascular disease, statins are the first line of treatment. It is available in oral tablet form.
Atorvastatin was patented in 1986 and it approved for medical use in the United States in 1996. It is available as a generic medication.
We learn this topic in below format
INDICATION OF ATORVASTATIN
- High cholesterol level
- Increase level of bad cholesterol or low density lipid level (LDL)
- Increase level of very low density lipid (VLDL)
- Secondary prophylaxis after myocardial infarction (heart attack)
- Also useful in increase level of triglyceride
We should avoid this medicine in mentioned conditions
- Hypersensitivity to this molecule
- Active liver disease
- Trauma or surgery
Atorvastatin may cause fetal harm by affecting cholesterol and triglyceride levels, which are necessary for fetal development. Also avoid during lactation.
DOSAGE OF ATORVASTATIN
If required than we can give upto 80mg once daily
Each & every molecule which have effect also have side-effect. But, it not occurs to everyone. It occurs to only who have sensitivity to particular molecule.
If adverse effect occurs, that may be one of below
- Nausea, vomiting, abdominal pain
- Headache, chest pain
- Hair loss (alopecia)
- Erectile dysfunction (impotense)
- Increase level of liver enzymes
- Monitor liver function test (LFT) before starting the treatment. Repeat LFT is advise by doctor after ongoing treatment.
- Use cautiously in liver disease or alcoholic patient
- Metabolic or endocrine disorder
- Safety not established in children
MECHANISM OF ACTION
- As with other statins, atorvastatin inhibit HMG-CoA reductase.
- Liver is the primary site of action of atorvastatin. Liver is the principal site where both cholesterol synthesis & LDL clearance.
- This way atorvastatin decreases total cholesterol and low density lipoprotein.
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