Aspirin medicine : Indication, Dosage, Adverse effect

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In this blog, we learn about Aspirin medicine which is also known as acetylsalicylic acid. 

aspirin medicine
aspirin structure

It is used to treat fever, pain or inflammation. Aspirin given shortly after heart attack, which decreases the risk of death. It also given for long term to prevent further heart attack, Ischaemic strokes, blood clots in people at high risk.

In 1897, scientists at the Bayer company began studying acetylsalicylic acid as a less-irritating replacement medication for common salicylate medicines. In 1899, Bayer give name “Aspirin” and sell it around the world.

We learn this topic in below format

INDICATION OF ASPIRIN

  • Fever & in inflammation
  • Osteoarthritis
  • Rheumatoid arthritis
  • Dental pain
  • Muscles pain
  • Rheumatic fever
  • Low dose of aspirin reduces the risk of death from a heart attack or brain stroke in people who are at higher risk or had heart attack earlier. But, it should given to older who are healthy otherwise.

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MECHANISM OF ACTION

It blocks prostaglandin synthesis by cyclo-oxygenase pathway. 

It inhibits thromboxane A2 formation in platelet reducing platelet aggregation.

How it controls fever?

Normal body temperature is 98.6 F, which is regulated by hypothalamus (brain)

When infection occurs, there is increase secretion of prostaglandin

Which causes disturbance in hypothalamus & due to that temperature increases called fever

After taking aspirin, this medicine blocks the synthesis of prostaglandin

So, for period of time hypothalamus works well & temperature decreases.

This way aspirin decreases the temperature for short period of time. Other medicines will control the infection. 

How it controls the pain

When we got injury, there is increase secretion of prostaglandin by our body

It causes nerve stimulation & so, we feel pain

After taking aspirin, it blocks the synthesis of prostaglandin

 
So, brain not recieved the message of pain temporarily

This way aspirin controls pain. With time injured part heal & patient will feel completely okay.

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DOSAGE OF ASPIRIN

Dosage of aspirin depends on disease condition 

Adult
Fever & pain
300mg to 500mg three time in a day

For anti-platelet effect
75 to 150mg once in a day

Children
30 to 65 mg/kg per day in three divided doses

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CONTRAINDICATIONS

In below conditions, we should avoid aspirin medicine 

  • If patient have hypersensitivity to this molecule
  • Gout – increase uric acid level in blood
  • Gastro intestinal bleeding
  • Hemophilia

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ONSET OF EFFEFT 

Effect starts within 30 minutes of taking aspirin. Its effect last for about 12 hours.

Antiplatelet effects may last for a few days.

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ADVERSE EFFECT OF ASPIRIN

Each & every molecule which have effect, it has also side-effect. We can not deny adverse effect or side-effect. But it is not happen to everybody, it only occurs to someone who have sensitivity to particular molecule.

If patient have known sensitivity to any medicine, than they should show it to your consulting doctor.

If adverse effect occurs than it may be one of below

  • Nausea, vomiting, epigastric distress
  • Indigestion
  • Rashes over body
  • Breathlessness, wheezing
  • Ringing in ear
  • Gastric irritation with slight asymptomatic blood loss
  • Reye’s syndrome
  • Cerebral haemorrhage in patient with preexisting lesions

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SPECIAL PRECAUTION

In below conditions, you have to take care to use this medicine

  • chronic kidney or liver disease
  • Peptic ulcer, hemorrhagic distress, cerebrovascular haemorrhage
  • Platlet disorder, hemophilia, hypoprothrombinaemia
  • Avoid prolonged use if not clearly indicated
  • It may cause more stomach irritation with alcohol

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BRAND NAMES & STRENTH 

Brand names
It is available in market with different brand names like ecosprin, spirin, aprin, disprin, caprin, etc.

Strenth
It is available in different power
50mg tablet
75mg  tablet
100mg tablet
150mg tablet
325mg tablet
400mg tablet, etc.

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