In this blog, we learn about Aspirin medicine which is also known as acetylsalicylic acid.
It is used to treat fever, pain or inflammation. Aspirin given shortly after heart attack, which decreases the risk of death. It also given for long term to prevent further heart attack, Ischaemic strokes, blood clots in people at high risk.
In 1897, scientists at the Bayer company began studying acetylsalicylic acid as a less-irritating replacement medication for common salicylate medicines. In 1899, Bayer give name “Aspirin” and sell it around the world.
We learn this topic in below format
INDICATION OF ASPIRIN
- Fever & in inflammation
- Rheumatoid arthritis
- Dental pain
- Muscles pain
- Rheumatic fever
- Low dose of aspirin reduces the risk of death from a heart attack or brain stroke in people who are at higher risk or had heart attack earlier. But, it should given to older who are healthy otherwise.
MECHANISM OF ACTION
It blocks prostaglandin synthesis by cyclo-oxygenase pathway.
It inhibits thromboxane A2 formation in platelet reducing platelet aggregation.
How it controls fever?
Normal body temperature is 98.6 F, which is regulated by hypothalamus (brain)
When infection occurs, there is increase secretion of prostaglandin
Which causes disturbance in hypothalamus & due to that temperature increases called fever
After taking aspirin, this medicine blocks the synthesis of prostaglandin
So, for period of time hypothalamus works well & temperature decreases.
This way aspirin decreases the temperature for short period of time. Other medicines will control the infection.
How it controls the pain
When we got injury, there is increase secretion of prostaglandin by our body
It causes nerve stimulation & so, we feel pain
After taking aspirin, it blocks the synthesis of prostaglandin
So, brain not recieved the message of pain temporarily
This way aspirin controls pain. With time injured part heal & patient will feel completely okay.
DOSAGE OF ASPIRIN
Dosage of aspirin depends on disease condition
Fever & pain
300mg to 500mg three time in a day
For anti-platelet effect
75 to 150mg once in a day
30 to 65 mg/kg per day in three divided doses
In below conditions, we should avoid aspirin medicine
- If patient have hypersensitivity to this molecule
- Gout – increase uric acid level in blood
- Gastro intestinal bleeding
ONSET OF EFFEFT
Effect starts within 30 minutes of taking aspirin. Its effect last for about 12 hours.
Antiplatelet effects may last for a few days.
ADVERSE EFFECT OF ASPIRIN
Each & every molecule which have effect, it has also side-effect. We can not deny adverse effect or side-effect. But it is not happen to everybody, it only occurs to someone who have sensitivity to particular molecule.
If patient have known sensitivity to any medicine, than they should show it to your consulting doctor.
If adverse effect occurs than it may be one of below
- Nausea, vomiting, epigastric distress
- Rashes over body
- Breathlessness, wheezing
- Ringing in ear
- Gastric irritation with slight asymptomatic blood loss
- Reye’s syndrome
- Cerebral haemorrhage in patient with preexisting lesions
In below conditions, you have to take care to use this medicine
- chronic kidney or liver disease
- Peptic ulcer, hemorrhagic distress, cerebrovascular haemorrhage
- Platlet disorder, hemophilia, hypoprothrombinaemia
- Avoid prolonged use if not clearly indicated
- It may cause more stomach irritation with alcohol
BRAND NAMES & STRENTH
It is available in market with different brand names like ecosprin, spirin, aprin, disprin, caprin, etc.
It is available in different power
400mg tablet, etc.
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